Stopping Ozempic or Wegovy often leads to rapid weight regain, study finds

People who stop taking popular weight‑loss drugs like Ozempic and Wegovy may quickly regain the weight they lost, according to a new review from the University of Oxford.

Researchers found that many patients return to their starting weight within two years of ending treatment. The analysis also shows the weight comes back even faster than it typically does for people who lose weight through diet and exercise alone.

GLP‑1 medications such as Ozempic and Wegovy work by mimicking a hormone that signals fullness to the brain and gut. But once the injections stop, experts warn the body may begin producing less of that natural hormone and may also become less sensitive to it — increasing the likelihood of overeating.