CJ Marable scored two touchdowns while rushing for 100 yards as the Chanticleers posted the most points since putting up 70 against Charleston Southern in 2010. Their 42 first-half points tied a school record as the Chanticleers led 42-14 going into the break.
Coastal Carolina (3-1) amassed 636 total yards while limiting the Minuteman to 306. The Chanticleer rushed for 302 yards and threw for 334.
Randall West threw for 108 yards and two TDs for winless UMass (0-4).
The Chanticleers, who opened the season with a 30-23 loss to Eastern Michigan, face Appalachian State next week.
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